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Total 200 results found since Jan 2013.
Identification of γ-Fagarine as a novel antiviral agent against respiratory virus (hMPV) infection
In this study, we aim to investigate the effect of γ-Fagarine on hMPV infection and explore its underlying molecular mechanisms. Vero-E6 and 16HBE cells were used as cell models. Virus replication and microcosm character were explored in Vero-E6 cells. Then, the antiviral activities were investigated by quantitative real-time PCR (RT-qPCR), western blotting (WB), and indirect immunofluorescence assays (IFAs) in Vero-E6 and 16HBE. Potential mechanisms of γ-Fagarine related to HSPG and lysosome pH were assessed in 16HBE cells. Lastly, a virus-infected mouse model was established and antiviral assay in vivo was conducted. Î...
Source: Virus Research - September 21, 2023 Category: Virology Authors: Jinhua Li Yao Zhao Ying Dai Junning Zhao Source Type: research
Association of vaccine-specific regulatory T cells with reduced antibody response to repeated influenza vaccination
This article is protected by copyright. All rights reserved.PMID:37713727 | DOI:10.1002/eji.202350525
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Pin-Hung Lin Po-Ju Hsiao Ching-Fu Pan Ming-Tsan Liu Jann-Tay Wang Chi Ching Fang-Yi Wu Yi-Hsuan Lin Yu-Chan Yang Le-Yin Hsu Hung-Chih Yang Un-In Wu Source Type: research
Comparative effectiveness of mRNA-1273 and BNT162b2 COVID-19 vaccines in immunocompromised individuals: a systematic review and meta-analysis using the GRADE framework
ConclusionThis GRADE meta-analysis based on a large number of consistent observational studies showed that the mRNA-1273 COVID-19 vaccine is associated with improved clinical effectiveness in IC populations compared with BNT162b2.
Source: Frontiers in Immunology - September 12, 2023 Category: Allergy & Immunology Source Type: research
Knowledge, attitudes, concern, behaviors, and barriers associated with the readiness to receive seasonal influenza vaccine among healthcare workers in oncology setting during the COVID-19 pandemic
This study examines the knowledge, attitudes, concerns, behaviors, and barriers related to seasonal influenza vaccination among healthcare workers (HCWs) in the oncology setting during the COVID-19 pandemic. The objective is to assess the readiness of HCWs to receive the influenza vaccine. A cross-sectional study was conducted at the King Hussein Cancer Center (KHCC) in Amman, Jordan. HCWs were surveyed using a self-administered web-based questionnaire between October 2021 and November 2021. Among 223 participants, the coverage rates for seasonal influenza vaccination ranged from 65% to 81% during the autumns of 2019 and 2...
Source: Cancer Control - August 28, 2023 Category: Cancer & Oncology Authors: Sawsan Mubarak Hadeel AlGhawrie Bayan Qaddumi Source Type: research
Predictors of Colonoscopy Use Among Asian Indians in New York City, 2003 to 2016
CONCLUSIONS: Among Asian Indians living in New York City, several demographic, socioeconomic, and health-related characteristics predict colonoscopy use. These findings highlight the importance of examining determinants of colonoscopy uptake in this understudied population to inform future public health interventions.PMID:37556383 | DOI:10.1097/MCG.0000000000001900
Source: Clinical Colorectal Cancer - August 9, 2023 Category: Cancer & Oncology Authors: Neha Nagpal Taylor M McCready Yuhe Xia Kevin Lin Matthew Glenn Sandy Ng Chau Trinh-Shevrin Andrea B Troxel Simona C Kwon Peter S Liang Source Type: research
Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues.
Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease
https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/
With the caveat that mouse models of Alzheimer's...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Impact of influenza vaccination on survival of patients with advanced cancer receiving immune checkpoint inhibitors (INVIDIa-2): final results of the multicentre, prospective, observational study
EClinicalMedicine. 2023 Jun 29;61:102044. doi: 10.1016/j.eclinm.2023.102044. eCollection 2023 Jul.ABSTRACTBACKGROUND: The prospective multicentre observational INVIDIa-2 study investigated the clinical effectiveness of influenza vaccination in patients with advanced cancer receiving immune checkpoint inhibitors (ICI). In this secondary analysis of the original trial, we aimed to assess the outcomes of patients to immunotherapy based on vaccine administration.METHODS: The original study enrolled patients with advanced solid tumours receiving ICI at 82 Italian Oncology Units from Oct 1, 2019, to Jan 31, 2020. The trial's pri...
Source: Cancer Control - July 12, 2023 Category: Cancer & Oncology Authors: Melissa Bersanelli Elena Verzoni Alessio Cortellini Raffaele Giusti Lorenzo Calvetti Paola Ermacora Marilena Di Napoli Annamaria Catino Valentina Guadalupi Giorgia Guaitoli Vieri Scotti Francesca Mazzoni Antonello Veccia Pamela Francesca Guglielmini Fabia Source Type: research
Multimodeling approach to evaluating the efficacy of layering pharmaceutical and nonpharmaceutical interventions for influenza pandemics
Proc Natl Acad Sci U S A. 2023 Jul 11;120(28):e2300590120. doi: 10.1073/pnas.2300590120. Epub 2023 Jul 3.ABSTRACTWhen an influenza pandemic emerges, temporary school closures and antiviral treatment may slow virus spread, reduce the overall disease burden, and provide time for vaccine development, distribution, and administration while keeping a larger portion of the general population infection free. The impact of such measures will depend on the transmissibility and severity of the virus and the timing and extent of their implementation. To provide robust assessments of layered pandemic intervention strategies, the Cente...
Source: Cancer Control - July 3, 2023 Category: Cancer & Oncology Authors: Pragati V Prasad Molly K Steele Carrie Reed Lauren Ancel Meyers Zhanwei Du Remy Pasco Jorge A Alfaro-Murillo Bryan Lewis Srinivasan Venkatramanan James Schlitt Jiangzhuo Chen Mark Orr Mandy L Wilson Stephen Eubank Lijing Wang Matteo Chinazzi Ana Pastore Y Source Type: research
Preventive health care in blood cancer survivors: results from the ABC study
CONCLUSIONS: Utilization of preventive care is high among German blood cancer survivors. To ensure widespread delivery and avoid redundancy, communication between oncologists and preventive care providers is essential.PMID:37395845 | DOI:10.1007/s00432-023-04984-9
Source: Clinical Genitourinary Cancer - July 3, 2023 Category: Cancer & Oncology Authors: Julia Baum Hildegard Lax Nils Lehmann Anja Merkel-Jens Dietrich W Beelen Karl-Heinz J öckel Ulrich D ührsen Source Type: research
Multimodeling approach to evaluating the efficacy of layering pharmaceutical and nonpharmaceutical interventions for influenza pandemics
Proc Natl Acad Sci U S A. 2023 Jul 11;120(28):e2300590120. doi: 10.1073/pnas.2300590120. Epub 2023 Jul 3.ABSTRACTWhen an influenza pandemic emerges, temporary school closures and antiviral treatment may slow virus spread, reduce the overall disease burden, and provide time for vaccine development, distribution, and administration while keeping a larger portion of the general population infection free. The impact of such measures will depend on the transmissibility and severity of the virus and the timing and extent of their implementation. To provide robust assessments of layered pandemic intervention strategies, the Cente...
Source: Cancer Control - July 3, 2023 Category: Cancer & Oncology Authors: Pragati V Prasad Molly K Steele Carrie Reed Lauren Ancel Meyers Zhanwei Du Remy Pasco Jorge A Alfaro-Murillo Bryan Lewis Srinivasan Venkatramanan James Schlitt Jiangzhuo Chen Mark Orr Mandy L Wilson Stephen Eubank Lijing Wang Matteo Chinazzi Ana Pastore Y Source Type: research
Preventive health care in blood cancer survivors: results from the ABC study
CONCLUSIONS: Utilization of preventive care is high among German blood cancer survivors. To ensure widespread delivery and avoid redundancy, communication between oncologists and preventive care providers is essential.PMID:37395845 | DOI:10.1007/s00432-023-04984-9
Source: Clinical Breast Cancer - July 3, 2023 Category: Cancer & Oncology Authors: Julia Baum Hildegard Lax Nils Lehmann Anja Merkel-Jens Dietrich W Beelen Karl-Heinz J öckel Ulrich D ührsen Source Type: research
